Need some advice about System.ComponentModel.Win32Exception

I'm a newbie so it's ok to yell at me. I searched and couldn't find anything that would help me out. My program throws this code and I was wondering if someone can assist me out on figuring out why.
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Description: The process was terminated due to an unhandled exception.
Exception Info: System.ComponentModel.Win32Exception
Stack:
at Microsoft.VisualBasic.ApplicationServices.WindowsFormsApplicationBase.DoApplicationModel()
at Microsoft.VisualBasic.ApplicationServices.WindowsFormsApplicationBase.Run(System.String[])
at WindowsApplication1.My.MyApplication.Main(System.String[])
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Using VS 2010 .Net 4.0 happens the two machines that I installed it on.

Thanks for the help.