VS 2010 Saving Items From Datagridview to Database?

I have a datagridview and items get populated to it from a MySQL Database.

My Goal is to creating a receipt and saving it to the database

So all the items in the datagridview need to get saved to the database.

or I don't care where I save it , as long as the vb.net application can retrieve the data. IE: Like for returns, or update the receipt.


So, How or what is a good way to do this?

:ehh::confused: